An introduction to the study of the origin, abundances and distribution of the elements and their isotopes in the Universe, with emphasis on the isotopic constraints into the conditions, events and processes that shaped our Solar System. Topics to be covered include: cosmology and the age of the Universe, the age of the Milky Way and the duration of nucleosynthesis, the fundamentals of isotopic fractionations, the key roles of isotopic anomalies in understanding Solar System dynamics, early Solar System chronology from short- and long-lived nuclei, chondritic meteorite components as clues to solar nebula and asteroid evolution, as well as planetary formation and chronology (e.g., Moon, Mars, Earth).